Article
Active allele loss of the androgen receptor gene contributes to loss of androgen receptor expression in female breast cancers.
Biochemical and biophysical research communications - 28 Aug 2000
Shan L, Yang Q, Nakamura M, Nakamura Y, Mori I, Sakurai T, Kakudo K
Abstract excerpt
Given the importance of androgen and androgen receptor (AR) in the control of female breast growth and the potential association with female breast cancer, we evaluated the AR expression in 114 female breast cancers and further analyzed why AR expression was lost. Immunohistochemical analysis revealed that 14.1% (17/114) of the tumors lost the AR expression completely. To unravel the molecular mechanism for AR...
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