Article
Linkage disequilibrium in inbred North African families allows fine genetic and physical mapping of triple A syndrome.
European journal of human genetics : EJHG - 1 Aug 2000
Hadj-Rabia S, Salomon R, Pelet A, Penet C, Rotschild A, de Laët M H, Chaouachi B, Hannachi R, Bakiri F, Brauner R, Chaussain J L, Munnich A, Lyonnet S
Abstract excerpt
Triple A syndrome (Allgrove syndrome, MIM No. 231550) is a rare autosomal recessive disorder characterised by ACTH-resistant adrenal insufficiency, achalasia of the cardia, and alacrimia. The triple A gene has been previously mapped to chromosome 12q13 in a maximum interval of 6 cM between loci D12S1629 and D12S312. Using linkage analysis in 12 triple A families, mostly originating from North Africa, we confirm...
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