Article
Assessing the relative incidence of mitochondrial DNA A3243G in migraine without aura with maternal inheritance.
Headache - 1 Jan 2000
Di Gennaro G, Buzzi M G, Ciccarelli O, Santorelli F M, Pierelli F, Fortini D, D'Onofrio M, Costa A, Nappi G, Casali C
Abstract excerpt
OBJECTIVE: To determine whether patients with migraine without aura with maternal "inheritance" are affected by a monosymptomatic form of the MELAS syndrome (mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes) or carry the most common mitochondrial DNA (mtDNA) mutation associated with MELAS, namely the A3243G transition in the transfer RNA (tRNA)Leu(UUR) gene. BACKGROUND: The association...
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