[The relations between electrical synapse and the mechanism of epilepsy in genetical epilepsy-prone rat].

Abstract excerpt

OBJECTIVE: To investigate the role of gap junction protein Cx32 formed electrical synapses in the pathogenesis of epilepsy. METHODS: Antisense oligodeoxynucleotides (ODN) techniques, intracerebroventricular injection, neuronal discharges in temporal cortex slices, in situ hybridization and immunohistochemistry were used. RESULTS: An antisense ODN for Cx32 100 micrograms was intracerebroventricularly injected once...

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