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Article

Mitochondrial impairment of human muscle in Friedreich ataxia in vivo.

Neuromuscular disorders : NMD - 1 Aug 2000

Vorgerd M, Schöls L, Hardt C, Ristow M, Epplen J T, Zange J

Abstract excerpt

Friedreich ataxia occurs due to mutations in the gene encoding the mitochondrial protein frataxin. This (31)P magnetic resonance spectroscopy study on the calf muscle of Friedreich ataxia patients provides in vivo evidence of a severe impairment of mitochondrial function. Mitochondrial adenosine triphosphate resynthesis was studied by means of the post-exercise recovery of phosphocreatine. After ischemic exercise...

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Source

Identifiers

PMID: 10899450
DOI: 10.1016/s0960-8966(00)00108-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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