Article
Molecular biology. Mothers setting boundaries.
Science (New York, N.Y.) - 23 Jun 2000
Thorvaldsen J L, Bartolomei M S
Abstract excerpt
Certain genes are only expressed at one allele, a phenomenon called imprinting. Although it is well established that one allele of certain imprinted genes is silenced through methylation, this does not appear to be the case for all imprinted genes. In a thoughtful Perspective, Thorvaldsen and Bartolomei discuss new findings showing that insertion of insulator elements (boundary regions) between the promoter of a...
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