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Article

Apoptosis regulation in the testis: Involvement of Bcl-2 family members

1 Jan 2000

Abstract excerpt

Using immunohistochemical techniques and Western blot analysis, the possible role of Bcl-2 family members Bax, Bcl-2, Bcl-x(s), and Bcl-x(l) in male germ cell density-related apoptosis and DNA damage induced apoptosis was studied. The apoptosis inducer Bax was localized in all mouse and human testicular cell types, but despite the fact that irradiation induces its transcriptional activator, p53 in the human, Bax...

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PMID: 10862001
DOI: 10.1002/1098-2795(200007)56:3<353::aid-mrd4>3.0.co;2-3

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