Article
Melatonin suppression by light in euthymic bipolar and unipolar patients.
Archives of general psychiatry - 1 Jun 2000
Nurnberger J I, Adkins S, Lahiri D K, Mayeda A, Hu K, Lewy A, Miller A, Bowman E S, Miller M J, Rau L, Smiley C, Davis-Singh D
Abstract excerpt
BACKGROUND: Previous studies have suggested that bipolar patients are supersensitive to light suppression of melatonin and that this may be a trait marker for genetic vulnerability. The present study was an attempt to replicate and extend this observation. Propranolol hydrochloride effects were compared with light effects because of the documented influence of beta-adrenergic receptors on melatonin production....
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