Article
Distribution of CAG repeat size in the dentatorubral and pallidoluysian atrophy (DRPLA) gene in a normal population in Taiwan.
Proceedings of the National Science Council, Republic of China. Part B, Life sciences - 1 Apr 2000
Hsieh M, Chiu M H, Lin Y H, Lin C H, Lu T M, Li S Y, Li C
Abstract excerpt
Dentatorubral and pallidoluysian atrophy (DRPLA) is an autosomal dominant neurodegenerative disorder with expansion of trinucleotide CAG repeats in the coding region of the gene. Expansion of the repeat tract beyond the normal range produces gene products with extended polyglutamine tracts. In this study, we analyzed the distribution of the CAG repeats in the DRPLA alleles in a normal Taiwanese population. We...
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