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Article

Genetic nature of individual frailty: comparison of two approaches.

Twin research : the official journal of the International Society for Twin Studies - 1 Mar 2000

Begun A Z, Iachine I A, Yashin A I

Abstract excerpt

The traditional frailty models used in genetic analysis of bivariate survival data assume that individual frailty (and longevity) is influenced by thousands of genes, and that the contribution of each separate gene is small. This assumption, however, does not have a solid biological basis. It may just happen that one or a small number of genes makes a major contribution to determining the human life span. To...

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PMID: 10808241
DOI: 10.1375/136905200320565698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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