Retinal cell addition and rod production depend on early stages of ocular melanin synthesis

Abstract excerpt

Retinal mitosis is regulated by dopa, a melanin precursor present in the developing retinal pigment epithelium. Its absence results in retinal deficits including a failure of approximately 30% of the rod population to develop. Here, (3)H-thymidine labelling is used to analyse patterns of cell addition spanning the main period of retinal development in rat litters containing both pigmented and albino phenotypes....

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