Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chondrosarcoma in a family with multiple hereditary exostoses.

The Journal of bone and joint surgery. British volume - 1 Mar 2000

Kivioja A, Ervasti H, Kinnunen J, Kaitila I, Wolf M, Böhling T

Abstract excerpt

Multiple hereditary exostoses is an autosomal dominant skeletal disorder in which there are numerous cartilage-capped excrescences in areas of actively growing bone. The condition is genetically heterogeneous, and at least three genes, ext1, ext2 and ext3 are involved. The reported risk for malignant transformation to chondrosarcoma has been from 0.6% to 2.8%. We have reviewed six generations of a family with 114...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Bones
Share to Bone Neoplasms
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chondrosarcoma

Share to Chromosomes, Human, Pair 11

Share to Exostoses, Multiple Hereditary

Share to Magnetic Resonance Imaging

Share to Pedigree

Source

Identifiers

PMID: 10755438
DOI: 10.1302/0301-620x.82b2 .10139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chondrosarcoma in a family with multiple hereditary exostoses.PMID 10755438Read ↗

Mutations in the EXT1 and EXT2 genes in hereditary multiple exostoses.Semantic proximity Read ↗

Somatic loss of an EXT2 gene mutation during malignant progression in a patient with hereditary multiple osteochondromas.Semantic proximity Read ↗

Molecular basis of multiple exostoses: mutations in the EXT1 and EXT2 genes.Semantic proximity Read ↗

Reevaluation of a genetic model for the development of exostosis in hereditary multiple exostosisSemantic proximity Read ↗

Novel EXT1 mutation identified in a pedigree with hereditary multiple exostoses.Semantic proximity Read ↗

Hereditary multiple exostoses (EXT): mutational studies of familial EXT1 cases and EXT-associated malignancies.Semantic proximity Read ↗

Mutation spectrum of EXT1 and EXT2 in the Saudi patients with hereditary multiple exostoses.Semantic proximity Read ↗

A novel deletion mutation of the EXT2 gene in a large Chinese pedigree with hereditary multiple exostosis.Semantic proximity Read ↗

[A new EXT2 mutation in a Chinese family with hereditary multiple exostoses].Semantic proximity Read ↗

EXT2-positive multiple hereditary osteochondromas with some features suggestive of metachondromatosis.Semantic proximity Read ↗

A Novel EXT1 Mutation Identified in a Family with Multiple Osteochondromas.Semantic proximity Read ↗

Three novel EXT1 and EXT2 gene mutations in Taiwanese patients with multiple exostoses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.