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Article

The pathogenic L392V mutation of presenilin 1 decreases the affinity to glycogen synthase kinase-3 beta.

Neuroscience letters - 14 Apr 2000

Gantier R, Gilbert D, Dumanchin C, Campion D, Davoust D, Toma F, Frébourg T

Abstract excerpt

Determination of the effects of presenilin 1 (PSEN1) mutations, involved in autosomal dominant early-onset Alzheimer's disease (ADEOAD), on the interaction between PSEN1 and binding proteins is essential to determine which interactions are involved in Alzheimer's disease (AD) pathogenesis. The PSEN1 binding protein glycogen synthase kinase-3 beta (GSK-3 beta) has been considered as a key protein in AD...

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Source

Identifiers

PMID: 10754226
DOI: 10.1016/s0304-3940(00)00949-6

Genes

PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The pathogenic L392V mutation of presenilin 1 decreases the affinity to glycogen synthase kinase-3 beta.PMID 10754226Read ↗

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