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Article

Lithium for prepubertal depressed children with family history predictors of future bipolarity: a double-blind, placebo-controlled study.

Journal of affective disorders - 1 Nov 1998

Geller B, Cooper T B, Zimerman B, Frazier J, Williams M, Heath J, Warner K

Abstract excerpt

BACKGROUND: Because of negative studies of TCAs for prepubertal major depressive disorder (PMDD) and because of the potentially high switch rate of PMDD to prepubertal bipolarity (BP), it was hypothesized that lithium would be efficacious treatment for PMDD in children who also had family history (FH) predictors of future BP. METHODS: A double-blind, placebo-controlled, and pharmacokinetically dosed study of...

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Identifiers

PMID: 10743849
DOI: 10.1016/s0165-0327(98)00178-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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