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Human male infertility: chromosome anomalies, meiotic disorders, abnormal spermatozoa and recurrent abortion

1 Jan 2000

Abstract excerpt

Human male infertility is often related to chromosome abnormalities. In chromosomally normal infertile males, the rates of chromosome 21 and sex chromosome disomy in spermatozoa are increased. Higher incidences of trisomy 21 (seldom of paternal origin) and sex chromosome aneuploidy are also found. XXY and XYY patients produce increased numbers of XY, XX and YY spermatozoa, indicating an increased risk of...

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PMID: 10711834
DOI: 10.1093/humupd/6.1.93

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