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Article

Folding and activity of circularly permuted forms of a polytopic membrane protein.

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2000

Beutler R, Ruggiero F, Erni B

Abstract excerpt

The transmembrane subunit of the Glc transporter (IICB(Glc)), which mediates uptake and concomitant phosphorylation of glucose, spans the membrane eight times. Variants of IICB(Glc) with the native N and C termini joined and new N and C termini in the periplasmic and cytoplasmic surface loops were expressed in Escherichia coli. In vivo transport/in vitro phosphotransferase activities of the circularly permuted...

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Identifiers

PMID: 10677487
DOI: 10.1073/pnas.0305463397
PMCID: PMC26459

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Source receipt: pubmed, retrieved 7 Sept 2026.

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