Article
Defining asthma in genetic studies.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Dec 1999
Koppelman G H, Meijer G G, Postma D S
Abstract excerpt
Genetic studies have been hampered by the lack of a gold standard to diagnose asthma. The complex nature of asthma makes it more difficult to identify asthma genes. Therefore, approaches to define phenotypes, which have been successful in other genetically complex diseases, may be applied to define asthma in genetic studies. These approaches include narrowing of the disease definition and use of intermediate...
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