Article
Prophylactic mastectomy and inherited predisposition to breast carcinoma.
Cancer - 1 Dec 1999
Hughes K S, Papa M Z, Whitney T, McLellan R
Abstract excerpt
Relative to her risk of breast carcinoma, the woman with a BRCA1 or BRCA2 gene mutation can be managed either by intensive screening (with or without chemoprevention) or by prophylactic mastectomy. Although it would be preferable to avoid prophylactic surgery, the current level of screening technology and the rudimentary state of chemoprevention do not guarantee a good outcome with intensive surveillance. A...
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