Article
Apoptosis cascade progresses during turnover of human trophoblast: analysis of villous cytotrophoblast and syncytial fragments in vitro.
Laboratory investigation; a journal of technical methods and pathology - 1 Dec 1999
Huppertz B, Frank H G, Reister F, Kingdom J, Korr H, Kaufmann P
Abstract excerpt
Growth and survival of the trophoblast layer of the human placenta depends on continuous incorporation of villous trophoblast stem cells (cytotrophoblast), by syncytial fusion, into the syncytiotrophoblast. Descriptive studies suggest that this process may be intimately related to apoptosis. We have analyzed the expression and activation of initiator and execution caspases, critical effectors of apoptosis, in...
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