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Article

Epidermolytic hyperkeratosis with polycyclic psoriasiform plaques resulting from a mutation in the keratin 1 gene.

Experimental dermatology - 1 Dec 1999

Michael E J, Schneiderman P, Grossman M E, Christiano A M

Abstract excerpt

Epidermolytic hyperkeratosis (EHK) is a genodermatosis caused by mutations in either the keratin 1 (K1) or keratin 10 (K10) genes, and characterized by erythroderma and blistering at birth, with development of a ribbed, ichthyotic hyperkeratosis and palmoplantar keratoderma. A wide variety of mutations within the highly conserved helix termination motifs of the central rod domains of the K1 or K10 genes correlate...

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Identifiers

PMID: 10597140
DOI: 10.1111/j.1600-0625.1999.tb00309.x

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