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Article

A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans.

Cell - 12 Nov 1999

Shirasu K, Lahaye T, Tan M W, Zhou F, Azevedo C, Schulze-Lefert P

Abstract excerpt

Barley Rar1 is a convergence point in the signaling of resistance to powdery mildew, triggered by multiple race-specific resistance (R) genes. Rar1 is shown to function upstream of H2O2 accumulation in attacked host cells, which precedes localized host cell death. We isolated Rar1 by map-based cloning. The sequence of the deduced 25.5 kDa protein reveals two copies of a 60-amino acid domain, CHORD, conserved in...

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PMID: 10571178
DOI: 10.1016/s0092-8674(00)81522-6

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