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Article

Functional analysis of aquaporin-2 mutants associated with nephrogenic diabetes insipidus by yeast expression.

The American journal of physiology - 1 Nov 1999

Shinbo I, Fushimi K, Kasahara M, Yamauchi K, Sasaki S, Marumo F

Abstract excerpt

Mutations of aquaporin-2 (AQP2) vasopressin water channel cause nephrogenic diabetes insipidus (NDI). It has been suggested that impaired routing of AQP2 mutants to the plasma membrane causes the disease; however, no determinations have been made of mutation-induced alterations of AQP2 channel water permeability. To address this issue, a series of AQP2 mutants were expressed in yeast, and the osmotic water...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10564236
DOI: 10.1152/ajprenal.1999.277.5.F734

Genes

AQP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Functional analysis of aquaporin-2 mutants associated with nephrogenic diabetes insipidus by yeast expression.PMID 10564236Read ↗

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