Article
A repeat polymorphism in interleukin-4 gene is highly associated with specific clinical phenotypes of asthma.
International archives of allergy and immunology - 1 Sept 1999
Chouchane L, Sfar I, Bousaffara R, El Kamel A, Sfar M T, Ismaïl A
Abstract excerpt
BACKGROUND: IL-4 is a determining factor in immunologic mechanisms to allergy and inflammation. The authors designed a case-controlled study to investigate the potential association of a repeat polymorphism in IL-4 gene with specific clinical phenotypes of asthma. METHODS: The authors used the polymerase chain reaction to characterize the variation of the IL-4 intron 2 region in 145 unrelated Tunisian patients...
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