A repeat polymorphism in interleukin-4 gene is highly associated with specific clinical phenotypes of asthma.

doi:10.1159/000024219

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Article

A repeat polymorphism in interleukin-4 gene is highly associated with specific clinical phenotypes of asthma.

International archives of allergy and immunology - 1 Sept 1999

Chouchane L, Sfar I, Bousaffara R, El Kamel A, Sfar M T, Ismaïl A

Abstract excerpt

BACKGROUND: IL-4 is a determining factor in immunologic mechanisms to allergy and inflammation. The authors designed a case-controlled study to investigate the potential association of a repeat polymorphism in IL-4 gene with specific clinical phenotypes of asthma. METHODS: The authors used the polymerase chain reaction to characterize the variation of the IL-4 intron 2 region in 145 unrelated Tunisian patients...

Topics

Adolescent
Adult
Alleles
Asthma
Base Sequence
Case-Control Studies
Child
DNA Primers
Female
Genotype
Humans
Interleukin-4
Introns
Male
Pedigree
Phenotype
Polymorphism, Genetic
Repetitive Sequences, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 10529588
DOI: 10.1159/000024219

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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