Article
Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other gram-negative bacteria.
Molecular microbiology - 1 Sept 1999
Holden M T, Ram Chhabra S, de Nys R, Stead P, Bainton N J, Hill P J, Manefield M, Kumar N, Labatte M, England D, Rice S, Givskov M, Salmond G P, Stewart G S, Bycroft B W, Kjelleberg S, Williams P
Abstract excerpt
In cell-free Pseudomonas aeruginosa culture supernatants, we identified two compounds capable of activating an N-acylhomoserine lactone (AHL) biosensor. Mass spectrometry and NMR spectroscopy revealed that these compounds were not AHLs but the diketopiperazines (DKPs), cyclo(DeltaAla-L-Val) and cyclo(L-Pro-L-Tyr) respectively. These compounds were also found in cell-free supernatants from Proteus mirabilis,...
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