Aging in a dish: Age‐dependent changes of neuronal survival, protein oxidation, and creatine kinase BB expression in long‐term hippocampal cell culture

Abstract excerpt

Results from different experimental systems demonstrate that increased oxidative damage plays a role in normal aging and age-associated pathology. In the current study, long-term cultures of hippocampal neurons were examined as a model system. It was established that neuronal survival in long-term culture decreases according to the Gompertz law and that neuronal "aging in the dish" is associated with increased...

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