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Article

Synthetic lethal phenotypes caused by mutations affecting chromosome partitioning in Bacillus subtilis.

Journal of bacteriology - 1 Sept 1999

Britton R A, Grossman A D

Abstract excerpt

We investigated the genetic interactions between mutations affecting chromosome structure and partitioning in Bacillus subtilis. Loss-of-function mutations in spoIIIE (encoding a putative DNA translocase) and smc (involved in chromosome structure and partitioning) caused a synthetic lethal phenotype. We constructed a conditional mutation in smc and found that many of the spoIIIE smc double-mutant cells had a...

Topics

Bacillus subtilis
Bacterial Proteins
Cell Cycle Proteins
Chromosomes, Bacterial
Genes, Bacterial
Genes, Lethal
Kinetics
Mutagenesis
Phenotype
Sigma Factor
Spores, Bacterial

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PMID: 10482533
DOI: 10.1128/JB.181.18.5860-5864.1999
PMCID: PMC94112

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