Article
Is an epitope on keratin 17 a major target for autoreactive T lymphocytes in psoriasis?
1 Sept 1999
Abstract excerpt
Psoriasis is a T cell-mediated inflammatory skin disease that has been associated with infections by group A beta-haemolytic streptococci. In a previous study of patients with active psoriasis we demonstrated an increased frequency of circulating Th1-like cells that responded to 20 amino acid (aa) streptococcal M-peptides sharing sequences with human keratin. These cells disappeared after ultraviolet B...
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