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Article

Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice.

The Journal of clinical investigation - 1 Aug 1999

Barton-Davis E R, Cordier L, Shoturma D I, Leland S E, Sweeney H L

Abstract excerpt

Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene, leading to the absence of the dystrophin protein in striated muscle. A significant number of these mutations are premature stop codons. On the basis of the observation that aminoglycoside treatment can suppress stop codons in cultured cells, we tested the effect of gentamicin on cultured muscle cells from the mdx mouse - an animal...

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Source

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Identifiers

PMID: 10449429
DOI: 10.1172/JCI7866
PMCID: PMC481050

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice.PMID 10449429Read ↗

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Read-through strategies for suppression of nonsense mutations in Duchenne/ Becker muscular dystrophy: aminoglycosides and ataluren (PTC124).Semantic proximity Read ↗

Drug‐induced readthrough of premature stop codons leads to the stabilization of laminin α2 chain mRNA in CMD myotubesSemantic proximity Read ↗

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