[Segregation and genetic-dispersion analysis of predisposition to adenoma and cancer of the large intestine].

Article

[Segregation and genetic-dispersion analysis of predisposition to adenoma and cancer of the large intestine].

Genetika - 1 Apr 1999

Belev N F, Samotyia E E, Pikhut P M, Kudina E N, Khalipli S D, Mazurin V Ia, Stratila V P, Trubnikov V I, Kazubskaia T P, Gar'kavtseva R F

Abstract excerpt

Segregation analysis of inheritance of adenomas, colorectal cancer (CRC), and multiple primary malignant tumors (MPMT) revealed their low penetrance: from 3.2 to 29% for homozygotes and from 2.0 to 14.4% for heterozygotes. This cast a doubt on the monogenic type of their inheritance, although it formally corresponded to the quasidominant type, i.e., only a fraction of heterozygotes was expressed. Therefore, the...

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