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Article

[Segregation and genetic-dispersion analysis of predisposition to adenoma and cancer of the large intestine].

Genetika - 1 Apr 1999

Belev N F, Samotyia E E, Pikhut P M, Kudina E N, Khalipli S D, Mazurin V Ia, Stratila V P, Trubnikov V I, Kazubskaia T P, Gar'kavtseva R F

Abstract excerpt

Segregation analysis of inheritance of adenomas, colorectal cancer (CRC), and multiple primary malignant tumors (MPMT) revealed their low penetrance: from 3.2 to 29% for homozygotes and from 2.0 to 14.4% for heterozygotes. This cast a doubt on the monogenic type of their inheritance, although it formally corresponded to the quasidominant type, i.e., only a fraction of heterozygotes was expressed. Therefore, the...

Topics

Adenoma
Analysis of Variance
Chromosome Segregation
Genetic Predisposition to Disease
Heterozygote
Humans
Intestinal Neoplasms
Intestine, Large

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 10420277

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