Article
[Congenital long QT syndrome. The value of genetics in prognostic evaluation].
Archives des maladies du coeur et des vaisseaux - 1 May 1999
Denjoy I, Lupoglazoff J M, Donger C, Berthet M, Richard P, Neyroud N, Villain E, Lucet V, Coumel P, Guicheney P
Abstract excerpt
The congenital long QT syndrome (QTL) is a heterogenic clinical and genetic entity characterised by prolongation of the QT interval which may be complicated by syncope and sudden death. Four genes have been identified for the cardiac potassium (KCNQ1, HERG and KCNE1) and sodium (SCN5A). The aim of this study was to assess the prognosis of the disease by the site of mutation identified on the morbid gene....
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