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Article

Leukaemia inhibitory factor gene mutations in infertile women

1 Jun 1999

Abstract excerpt

The glycoprotein leukaemia inhibitory factor (LIF) is produced by the endometrium and is involved in the control of implantation. In women with unexplained infertility reduced uterine concentrations of LIF have been reported. Studies with mice lacking a functional LIF gene have shown that the LIF protein is essential for implantation of the embryo. We have developed a method for screening of gene mutations in the...

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PMID: 10341007
DOI: 10.1093/molehr/5.6.581

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