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Article

α-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy

15 May 1999

Abstract excerpt

We identified the alpha-cardiac actin gene (ACTC) as a novel disease gene in a pedigree suffering from familial hypertrophic cardiomyopathy (FHC). Linkage analyses excluded all the previously reported FHC loci as possible disease loci in the family studied, with lod scores varying between -2.5 and -6.0. Further linkage analyses of plausible candidate genes highly expressed in the adult human heart identified ACTC...

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PMID: 10330430
DOI: 10.1172/jci6460

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