Differential and inefficient splicing of a broadly expressed Drosophila erect wing transcript results in tissue-specific enrichment of the vital EWG protein isoform.

doi:10.1128/MCB.19.6.3998

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Differential and inefficient splicing of a broadly expressed Drosophila erect wing transcript results in tissue-specific enrichment of the vital EWG protein isoform.

Molecular and cellular biology - 1 Jun 1999

Koushika S P, Soller M, DeSimone S M, Daub D M, White K

Abstract excerpt

In this report, we document an unusual mode of tissue-enriched gene expression that is primarily mediated by alternative and inefficient splicing. We have analyzed posttranscriptional regulation of the Drosophila erect wing gene, which provides a vital neuronal function and is essential for the formation of certain muscles. Its predominant protein product, the 116-kDa EWG protein, a putative transcriptional...

Topics

Alternative Splicing
Animals
Crosses, Genetic
DNA Primers
Drosophila Proteins
Drosophila melanogaster
Fetal Viability
Immunoblotting
Introns
Models, Genetic
Mutagenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuropeptides

Nuclear Proteins

Phenotype

RNA Processing, Post-Transcriptional

Reverse Transcriptase Polymerase Chain Reaction

Tissue Distribution

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 10330140
DOI: 10.1128/MCB.19.6.3998
PMCID: PMC104359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential and inefficient splicing of a broadly expressed Drosophila erect wing transcript results in tissue-specific enrichment of the vital EWG protein isoform.PMID 10330140Read ↗

The Drosophila erect wing gene, which is important for both neuronal and muscle development, encodes a protein which is similar to the sea urchin P3A2 DNA binding protein.Semantic proximity Read ↗

Conserved regions of the Drosophila erect wing protein contribute both positively and negatively to transcriptional activity.Semantic proximity Read ↗

ERECT WING, the Drosophila member of a family of DNA binding proteins is required in imaginal myoblasts for flight muscle development.Semantic proximity Read ↗

Differential expression and function of the Drosophila Pax6 genes eyeless and twin of eyeless in embryonic central nervous system development.Semantic proximity Read ↗

Functional differences between Ultrabithorax protein isoforms in Drosophila melanogaster: evidence from elimination, substitution and ectopic expression of specific isoforms.Semantic proximity Read ↗

Prader-Willi locus <i>Snord116</i> RNA processing requires an active endogenous allele and neuron-specific splicing by <i>Rbfox3/NeuN</i>Semantic proximity Read ↗

Tissue-specific splicing and functions of the Drosophila transcription factor Grainyhead.Semantic proximity Read ↗

Transcript isoforms of Reep6 have distinct functions in the retina.Semantic proximity Read ↗

Essential and neural transcripts from the Drosophila shaking-B locus are differentially expressed in the embryonic mesoderm and pupal nervous system.Semantic proximity Read ↗

Acetylcholinesterase Expression in Muscle Is Specifically Controlled by a Promoter-Selective Enhancesome in the First IntronSemantic proximity Read ↗

Tissue-specific promoter usage and diverse splicing variants of found in neurons, an ancestral Hu/ELAV-like RNA-binding protein gene of insects, in the direct-developing insect Gryllus bimaculatus.Semantic proximity Read ↗

Sxl-Dependent, tra/tra2-Independent Alternative Splicing of the Drosophila melanogaster X-Linked Gene found in neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.