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Article

First unaffected pregnancy using preimplantation genetic diagnosis for sickle cell anemia.

JAMA - 12 May 1999

Xu K, Shi Z M, Veeck L L, Hughes M R, Rosenwaks Z

Abstract excerpt

CONTEXT: Sickle cell anemia is a common autosomal recessive disorder. However, preimplantation genetic diagnosis (PGD) for this severe genetic disorder previously has not been successful. OBJECTIVE: To achieve pregnancy with an unaffected embryo using in vitro fertilization (IVF) and PGD. DESIGN: Laboratory analysis of DNA from single cells obtained by biopsy from embryos in 2 IVF attempts, 1 in 1996 and 1 in...

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Source

Identifiers

PMID: 10328069
DOI: 10.1001/jama.281.18.1701

Genes

PGD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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