Article
Platelet adenylyl cyclase activity as a biochemical trait marker for predisposition to alcoholism.
Alcoholism, clinical and experimental research - 1 Apr 1999
Ratsma J E, Gunning W B, Leurs R, Schoffelmeer A N
Abstract excerpt
Previous studies demonstrated a reduced Gs-protein stimulated adenylyl cyclase activity in the brain and blood cells of alcoholics. We investigated this phenomenon in platelets of children of alcoholics (COA), i.e., of children at high risk for the acquisition of alcoholism and (as yet) not regularly consuming alcohol. Gs-protein mediated stimulation of adenylyl cyclase by 30 mM NaF and 50 microM forskolin...
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