Article
Osteogenic phenotype expression of allogeneic rat marrow cells in porous hydroxyapatite ceramics.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 1999
Akahane M, Ohgushi H, Yoshikawa T, Sempuku T, Tamai S, Tabata S, Dohi Y
Abstract excerpt
Porous hydroxyapatite (HA) ceramics were combined with either allogeneic (ACI) or isogeneic (Fischer 344) rat marrow cells and implanted in subcutaneous sites of Fischer rats. FK506 as an immunosuppressant or saline was administered to the recipient rats. The implanted marrow/HA composites were harvested on day 28 and analyzed for bone-forming capability by determining osteoblastic phenotype expression levels of...
Topics
- Alkaline Phosphatase
- Animals
- Bone Marrow Transplantation
- Ceramics
- Gene Expression
- Hydroxyapatites
- Immunosuppressive Agents
- Male
- Osteocalcin
- Osteogenesis
- Phenotype
- RNA, Messenger
- Rats
- Rats, Inbred ACI