Article
Type 4 cyclic adenosine monophosphate-specific phosphodiesterases are expressed in discrete subcellular compartments during rat spermiogenesis.
Endocrinology - 1 May 1999
Salanova M, Chun S Y, Iona S, Puri C, Stefanini M, Conti M
Abstract excerpt
The type 4 cAMP-specific phosphodiesterases (PDE4) are a family of closely related enzymes with similar catalytic domains and divergent amino- and carboxyl-terminus domains. Multiple PDE proteins with heterogeneous amino termini are derived from each gene. To understand the significance of this heterogeneity, the expression and localization of variants derived from PDE4A and PDE4D genes was investigated during...
Topics
- 3',5'-Cyclic-AMP Phosphodiesterases
- Animals
- Fluorescent Antibody Technique
- Follicle Stimulating Hormone
- Gene Expression
- Genetic Variation
- Isoenzymes
- Male
- Microscopy, Immunoelectron
- RNA Splicing
- RNA, Messenger
- Rats
- Rats, Sprague-Dawley