Article
Heart involvement in muscular dystrophies due to sarcoglycan gene mutations.
Muscle & nerve - 1 Apr 1999
Melacini P, Fanin M, Duggan D J, Freda M P, Berardinelli A, Danieli G A, Barchitta A, Hoffman E P, Dalla Volta S, Angelini C
Abstract excerpt
Mutations in the sarcoglycan genes cause autosomal-recessive muscular dystrophies. Because sarcoglycan genes and their protein products are highly expressed both in skeletal and cardiac muscle, patients with these mutations might be expected to be at risk to develop dilated cardiomyopathy. We therefore studied 13 patients with alpha-, beta-, gamma-sarcoglycan gene mutations by thorough cardiological assessment....
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