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Article

Human Cytomegalovirus Binding to Human Monocytes Induces Immunoregulatory Gene Expression

1 Apr 1999

Abstract excerpt

To continue our investigation of the cellular events that occur following human CMV (HCMV) infection, we focused on the regulation of cellular activation following viral binding to human monocytes. First, we showed that viral binding induced a number of immunoregulatory genes (IL-1beta, A20, NF-kappaB-p105/p50, and IkappaBalpha) in unactivated monocytes and that neutralizing Abs to the major HCMV glycoproteins,...

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PMID: 10202024
DOI: 10.4049/jimmunol.162.8.4806

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