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Article

Tumor necrosis factor-? initiated signal transduction in 3T3-L1 adipocytes

1 Apr 1999

Abstract excerpt

Examination of the ability of tumor necrosis factor-alpha (TNF) to activate both the p44/42 and p38 MAP kinase cascades in fully differentiated 3T3-L1 adipocytes indicated a rapid MEK1/2-dependent activation of p44/42 MAP kinase. Use of the MEK1/2 inhibitor PD98059 indicated that this pathway at least in part was responsible for nuclear localization of the transcription factor NF-kappaB. The...

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PMID: 10082133
DOI: 10.1002/(sici)1097-4652(199904)179:1<58::aid-jcp8>3.0.co;2-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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