Article
Genetic studies suggest a multicentric origin for Hb G-Coushatta [beta22(B4)Glu-->Ala].
Hemoglobin - 1 Feb 1999
Li J, Wilson D, Plonczynski M, Harrell A, Cook C B, Scheer W D, Zeng Y T, Coleman M B, Steinberg M H
Abstract excerpt
Hb G-Coushatta [beta22(B4)Glu-->Ala] is found in geographically separated ethnic groups. Commonest along the Silk Road region of China but also present in the North American Coushatta, we sought to determine whether this variant had a unicentric or multicentric origin. We examined the haplotype of the beta-globin gene cluster in two Chinese families and in five Louisiana Coushatta heterozygous for this mutation....
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