Article
Autoimmunity resulting from cytokine treatment predicts long-term survival in patients with metastatic renal cell cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Feb 1999
Franzke A, Peest D, Probst-Kepper M, Buer J, Kirchner G I, Brabant G, Kirchner H, Ganser A, Atzpodien J
Abstract excerpt
PURPOSE: In patients undergoing cytokine therapy, systemically applied interleukin-2 (IL-2) and/or interferon-alpha (IFN-alpha) have been reported to induce thyroid dysfunction as well as thyroid autoantibodies. We analyzed the correlation of thyroid autoimmunity with HLA phenotype, various other autoimmune parameters, and patient survival. PATIENTS AND METHODS: For this purpose, antithyroglobulin autoantibodies,...
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