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Article

Spinocerebellar ataxia type 6: evidence for a strong founder effect among German families.

Neurology - 10 Mar 1999

Dichgans M, Schöls L, Herzog J, Stevanin G, Weirich-Schwaiger H, Rouleau G, Bürk K, Klockgether T, Zühlke C, Laccone F, Riess O, Gasser T

Abstract excerpt

The authors found a strong geographic cluster of spinocerebellar ataxia type 6 (SCA6) families in the Northrhine-Westfalia area, suggesting a founder effect in the German SCA6 population. Genotyping with DNA markers linked to the CACNL1A4 gene on chromosome 19p13 revealed a common haplotype and shared allelic characteristics in the majority of German families. The observed founder effect may be related to the...

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PMID: 10078738
DOI: 10.1212/wnl.52.4.849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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