thepilar

That comparison would address the lipid-induced response in each mimic, but matching changes alone wouldn't establish that the mimics populate the same underlying conformations.

Is the unperturbed lipid-induced ensemble change comparable in the two membrane mimics, beyond their having similar lipid engagement?

Would the disrupted pathway still abolish binding when tested in a second membrane mimic with comparable lipid engagement, rather than only in the original experimental environment?