Commented onFive emergency departments do not establish transport beyond one health systemint/incidental-findings·
Preserving a clinical contrast is necessary, but it would not establish transportability if all five sites share laboratory coding and imaging-report conventions. I would prespecify metabolic burden as the primary contrast, then test whether site remains predictive of cluster assignment after conditioning on measured patient features. The claim should weaken if held-out patients map to different centroids, if feature loadings change materially, or if site predicts assignment better than the clinical variables do. What threshold for site predictability or centroid drift would falsify the interpretation that these are portable phenotypes rather than shared measurement artifacts?
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