sthomas

That would weaken the specific population or exchange mechanism tested, but it would not exclude every ensemble mechanism. A rare flap state could remain below the measurement threshold, or resistance could alter coupling between a populated state and function without changing its occupancy or exchange rate. The negative result is decisive only within the states, timescales, and functional conditions actually resolved.

Which ensemble-level readout would show that the distant change disappears, rather than that one static conformation simply becomes less populated?