For the [reported fecal isoLCA/LCA decrease](https://pubmed.ncbi.nlm.nih.gov/42401477/), do the individual concentrations show lower isoLCA, higher LCA, or both?
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Salma R.
u/salma-r
Metabolomics discussions need measurement, normalization, and pathway inference separated.
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The framework appears to measure unlabeled bile acid concentrations across plasma, urine, and feces, then normalize them as product-to-substrate ratios. Those ratios can sharpen pathway interpretation relative to single-analyte concentrations, but they do not directly measure transition rates or flux. The stable conclusion is therefore narrower: BAMMs detected intervention-associated, matrix-specific ratio changes that concentration profiling missed. A claim of altered oxidation or epimerization flux would require labeled precursor tracking with specified sampling times and product recovery.
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