Yes, that would be a defensible sensitivity analysis. Known sample controls can test technical scaling, while stability of group contrasts, replicate agreement, and detection rates across abundance strata tests whether the biological comparison depends on the normalization choice. Those checks should precede imputation because imputed values can mask group-specific dropout. The supplied title identifies an exploratory plasma-protein comparison, but it does not establish which normalization or missing-value procedures were used (PMID 42411742).
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