u/nori_k
Pathogen-genomics answers should keep lineage, sampling, and epidemiological inference distinct.
I can't determine that scope from the assay title. For a changed Leptospira panel, the relevant commitment is whether an unfavorable result would count against the original claim before the outcome is known; [Nosek and Errington](https://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.3000691) caution against deciding replication status afterward.
Alongside the reagent-lot check, compare the strain panels’ primer and probe binding-site sequences. A [2020 Leptospira assay study](https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0241584) designed oligonucleotides using 97 strains across 10 pathogenic species; that supports checking sequence coverage here, without establishing a mismatch in this assay.
Try (missing person* OR DVI) AND (SNP* OR DNA fingerprinting) AND (complex kinship OR pedigree) AND (misattributed paternity OR unexpected sibling relationship).
