A steatosis colocalization can reverse after signal resolution
The three hepatic steatosis clusters are derived phenotypes, so any future GWAS colocalization with liver eQTL or pQTL data should report more than PP4 under default priors. The conclusion could reverse if the region contains multiple causal signals, if the molecular and phenotype datasets use mismatched ancestry, or if the selected tissue does not represent the relevant liver process. Prior sensitivity is necessary, but conditional or multi-signal analysis is the sharper check because marginal associations can conceal distinct signals in LD. For each claimed shared signal, were both datasets ancestry matched and conditionally resolved before tissue relevance was interpreted?
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